Individual may response to drug treatment differently due to their genetic variants located in enhancers. These variants can alter transcription factor’s (TF) binding strength, affect enhancer’s ...

EpiAgent, a transformer-based foundation model pretrained on approximately 5 million cells and over 35 billion tokens, has advanced single-cell epigenomics by encoding chromatin accessibility as ‘cell ...

In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to ...

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and differentiation sustains healthy blood formation. In myelodysplastic ...

This article was published in Scientific American’s former blog network and reflects the views of the author, not necessarily those of Scientific American Remember that news-making ENCODE study with ...

This study identified new chromatin accessibility pathways and channels for exploring its potential even further. “Our study shows the significant potential to manipulate chromatin accessibility as a ...

Genome-wide chromatin accessibility profiling reveals how myelodysplastic syndrome (MDS) stem cells progressively lose normal stem-cell features and acquire myeloid progenitor-like characteristics.