This illustrative rendering of a 2.1 Mb region on chromosome 20 shows eight domains, six of which are demarcated by loops between convergent CTCF-binding sites located at the domain boundaries. The ...

The R loop is a nucleic acid ménage à trois in which RNA inserts between the two DNA strands, hybridizing with one and forcing the other to bulge out. Identifying the genomic location of R loops is ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published in Nature. Subscribe to our newsletter for the latest sci-tech news updates.

Because I find it hard to relate to something as small as the structure of the human genome, I like to imagine it scaled up a millionfold. At this size, each DNA molecule—a chromosome—is as wide as a ...