Women are twice as likely as men to receive replacement and have higher rates of recurrent MR, but survival is similar.

Large public datasets of the human microbiome now exist but combining them for large-scale analysis is difficult due to a lack of standardization. We developed curatedMetagenomicData (cMD) 3, a ...

The benefit of beta-blockers after myocardial infarction in patients with a preserved left ventricular ejection fraction (LVEF) is unclear. We conducted a meta-analysis at the individual-patient level ...

Ten-year follow-up data show similar mortality with PCI and CABG in selected patients, adding new evidence to the ...

Obesity is a major health challenge. Here we show that body mass index is positively associated with risk of 19 cancers and inversely associated with 3, based on a systematic review and meta-analysis ...

Background Chemotherapy-induced cardiotoxicity is a major contributor to long-term cardiovascular morbidity among cancer ...

Objective To synthesise meta-analytic outcomes from randomised controlled trials examining exercise effects on depression and anxiety across all population groups, including children and adults with ...

Objective To systematically review hip and groin injury (HGI) incidence, burden, prevalence and the proportion of HGI relative to all injuries in competitive sports. A secondary aim was to determine ...