Human immunoglobulin G (IgG) agonistic antibodies targeting costimulatory immunoreceptors represent promising cancer immunotherapies yet to be developed. Whether, and how, human IgG hinge and Fc ...

Neuro-immune dysfunction and inflammation are said to be involved in the aetiology of major mental illnesses. This study describes the assessment of the protease-like catalytic function of serum IgG ...

Aging, a phenomenon that affects every individual, is a natural part of the human condition but one that often induces anxiety. These feelings are paired with health conditions and illnesses that ...

Deleting a single amino acid (Pro230) in the lower hinge produced half-IgG1 molecules with disrupted disulfide bonds and reoriented Fab and Fc regions, highlighting the hinge’s essential role in ...

The lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control hub, according to a study by researchers at Science Tokyo. Deleting a single ...

Details and references regarding individual diseases are provided in the Supplementary Appendix. CIDP denotes chronic inflammatory demyelinating polyneuropathy, Covid-19 coronavirus disease 2019, and ...